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Cell Disrupter Selection Table

  Animal Tissue Plant Tissue Yeast and Fungi Bacteria Disrupt Speed(b) Relative Cost(c) Requires Cooling? Requires Prechop? Scale-up Available?
Bead-Beater and Mini-Bead-Beater, Mini-Bead-Beater-8, Mini-Bead-Beater-96 aa a aaa aaa 3 2 Yes Yes Yes
Sonozap a   aa 1-2 2 Yes Yes No No
Tissue-Tearor and BioHomogenizer aaa a
<1 2 No Yes Yes Yes
Hamilton-Beach Blenders aa aa 1-2 2 No No Yes
Cryo-Cup
Mortar & Pestle
(a) and
Mircro CryoCrusher(a)
aa aa 1 1 No Yes No
Tissue Grinder(a) aa aa 5 2 No Yes No
MicroMincer and Tissue Press(a) aa a 1 1&2 No No No
BioPulverizer(a) aa aa 0.1 2 No No No

Table Key:

(a) Fragments tissue but does not usually disrupt cells. Often used as a preliminary step.
(b) Typical minutes for 90 percent cell disruption.
(c) Purchase price range:

  1. $10 - $100,
  2. $100 - $1000,
  3. $1000 and up